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Description

AOD9604 is commonly used in vitro to explore mechanisms of fat metabolism, cell signaling, and metabolic regulation

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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

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Nevertheless, doxycycline efficiently induced OSKM in the colon and stomach in the presence of ABX (Extended Data Fig

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